Matching 2D Patterns of Protein Spots

Frank Hoffmann
Institut für Informatik
Freie Universität Berlin
Takustr. 9, D-14195 Berlin, Germany
email: hoffmann@inf.fu-berlin.de

Klaus Kriegel
Institut für Informatik
Takustr. 9, D-14195 Berlin, Germany
email: kriegel@inf.fu-berlin.de

Carola Wenk
Institut für Informatik
Takustr. 9, D-14195 Berlin
email: wenk@inf.fu-berlin.de

Report B 97-13
November 1997

A new algorithmic approach to comparing 2D patterns of protein spots obtained by the 2D gel electrophoresis technique is presented. Both the matching of a local pattern vs. a full 2D gel image and the global matching between full images are discussed. The local matching algorithm relies on a data structure derived from the incremental Delaunay triangulation of a point set and a 2-step hashing technique. The approach for the global matching uses local matching for landmark settings, which in previous algorithmic solutions has been done interactively by the user.

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