Biochemical and molecular foundations of bioinformatics
Algorithmic aspects of genome assembly
Chris Weise
(Freie Universität Berlin)
In this introductory lecture I will present some basic aspects of biochemistry. I will explain the relation between nucleic acids as an information store and proteins as the executors of diverse cellular functions. I will then focus on proteins, discussing the relation between structure and function and going through the different structural levels and the fundamental chemical interactions which determine their structure. I will set forth the importance of proteomics research in the "post-genome era" and try to define where, from a biochemist's point of view, there are possible interfaces
between biochemistry and informatics.
Daniel Huson
(Celera Genomics Corp., Rockville, Maryland)
In modern biology, knowledge of the complete genome of a species is
seen as a fundamental step towards it's full understanding.
The unraveling of the human genome, in particular, is of great
scientific
importance, and publication of a first draft of the human genome is
expected by the end of the year.
We will first review a number of different sequencing and assembly
strategies and then focus on some of the associated algorithmic
problems.
[home] - [up] - [top] | last modified on: October 31, 2000 |